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551 - ‘A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21’. Nature genetics. 39(7), pp.827-829

Reference Number: 551

Year: 2007

Authors: Van Heel et al.

Link: Link to original paper

Intolerance & Sensitivity: Coeliac

Summary

Abstract
We tested 310,605 single-nucleotide polymorphisms for association in 778 celiac disease cases and 1422 controls. Outside the HLA, the most significant finding (rs13119723, P=2.0 × 10?7, empirical genome-wide significance P=0.045) was in the KIAA1109/Tenr/IL2/IL21 linkage disequilibrium block. Association was independently confirmed in two further collections (strongest at rs6822844, 24kB 5′ of IL21, meta-analysis P=1.3 × 10?14, OR 0.63), suggesting genetic variation in this region predisposes to celiac disease.

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