Reference Number: 551
Intolerance & Sensitivity: Coeliac
We tested 310,605 single-nucleotide polymorphisms for association in 778 celiac disease cases and 1422 controls. Outside the HLA, the most significant finding (rs13119723, P=2.0 × 10?7, empirical genome-wide significance P=0.045) was in the KIAA1109/Tenr/IL2/IL21 linkage disequilibrium block. Association was independently confirmed in two further collections (strongest at rs6822844, 24kB 5′ of IL21, meta-analysis P=1.3 × 10?14, OR 0.63), suggesting genetic variation in this region predisposes to celiac disease.