A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

551 - ‘A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21’. Nature genetics. 39(7), pp.827-829

Reference Number: 551

Year: 2007

Authors: Van Heel et al.

Link: Link to original paper

Intolerance & Sensitivity: Coeliac

Summary

Abstract
We tested 310,605 single-nucleotide polymorphisms for association in 778 celiac disease cases and 1422 controls. Outside the HLA, the most significant finding (rs13119723, P=2.0 × 10?7, empirical genome-wide significance P=0.045) was in the KIAA1109/Tenr/IL2/IL21 linkage disequilibrium block. Association was independently confirmed in two further collections (strongest at rs6822844, 24kB 5′ of IL21, meta-analysis P=1.3 × 10?14, OR 0.63), suggesting genetic variation in this region predisposes to celiac disease.

All reasonable care is taken when writing about health aspects of bread, but the information it contains is not intended to take the place of treatment by a qualified medical practitioner. You must seek professional advice if you are in any doubt about any medical condition. Any application of the ideas and information contained on this website is at the reader’s sole discretion and risk.