178 - ‘A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease’. Am J Clin Nutr. 85, 160-166

Reference Number: 178

Year: 2007

Authors: Carlo Catassi, Elisabetta Fabiani, Giuseppe Iacono, Cinzia D’Agate, Ruggiero Francavilla, Federico Biagi, Umberto Volta, Salvatore Accomando, Antonio Picarelli, Italo De Vitis, Giovanna Pianelli, Rosaria Gesuita, Flavia Carle, Alessandra Mandolesi, Italo Bearzi, and Alessio Fasano

Link: Link to original paper

Intolerance & Sensitivity: Coeliac

Summary

Background: Treatment of celiac disease (CD) is based on the avoidance of gluten-containing food. However, it is not known whether trace amounts of gluten are harmful to treated patients.

Objective: The objective was to establish the safety threshold of prolonged exposure to trace amounts of gluten (ie, contaminating gluten).

 

 

SIGNIFICANCE OF THIS STUDY

The allowable level of gluten contamination in products labelled as suitable for people with celiac disease varies from one country to another. This study investigates response shown by celiacs over a three month period to different levels of gluten intake. It found large variation in patient’s responses to gluten intake at different levels, and suggests this complicates the issue of setting uniform guidelines for maximum gluten contamination.

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