Reference Number: 186
Year: 2018
Link: Link to original paper
Intolerance & Sensitivity: Coeliac
Summary
Celiac disease (CD) develops in genetically susceptible individuals as a result of ingesting gluten-forming proteins found in cereals, such as wheat (Triticum aestivum L.), rye (Secale cereale L.) and barley (Hordeum sativum L.). There are claims that breeding practices have changed wheat protein chemistry over the years and this has resulted in modern wheat being more antigenic in terms of CD as opposed to historical wheat. The aim of this study was to detect and quantify celiac-disease-initiating peptides of ?-gliadin proteins in historical and modern spring wheat cultivars. The results indicate that immunogenic epitopes are detected in both historical and modern spring wheat cultivars irrespective of release year. Quantitation indicated that the amount of immunogenic epitopes glia-?9 (PFPQPQLPY) and glia-?20 (FRPQQPYPQ), and total ?-gliadin varied randomly across the cultivars that were analyzed, suggesting there is no association between cultivar release year and amounts of immunogenic epitopes and ?-gliadin.
SIGNIFICANCE OF THIS STUDY
While there have been suggestions that modern wheat varieties are more likely to cause an immune response in people with coeliac disease, this study found no evidence of higher levels of antigens in modern wheat compared with historic varieties.