Causative role of gut microbiota in non-alcoholic fatty liver disease pathogenesis

213 - ‘Causative role of gut microbiota in non-alcoholic fatty liver disease pathogenesis’. Frontiers in Cellular and Infection Microbiology. 2, 132

Reference Number: 213

Year: 2012

Authors: Alisi A., et al

Link: Link to original paper

Health: Gut Microbiome - Creating Healthier Bread to Support Optimal Gut Health | Liver disease

Summary

Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide. NAFLD affects prevalently children and adults with particular risk factors including genetic susceptibility and inappropriate lifestyle (i.e., over-/mal-nutrition and physical inactivity). In fact, obesity, as well as some traits of metabolic syndrome, such as insulin resistance and dyslipidemia, are co-morbidities often associated to the presence of NAFLD . In line with the increased obesity epidemics, epidemiological studies indicate that the estimated global prevalence of NAFLD ranges from 3–10% depending on age, sex, ethnicity, and risk factors. Interestingly, in obese children and adults this prevalence may raise up to 20–80%.

SIGNIFICANCE OF THIS STUDY

The gut microbiota could be a factor in the development of NAFLD. The use of probiotics as part of a healthy diet have the potential to reverse the symptoms of this form of liver disease.

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