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558 - ‘Inflammation as “common soil” of the multifactorial diseases’. Autoimmunity reviews. 10(7), pp.369-374

Reference Number: 558

Year: 2011

Authors: Scrivo, R., Vasile, M., Bartosiewicz, I. and Valesini, G.

Link: Link to original paper

Health: Inflammation

Summary

Abstract

Inflammation is classically recognized as an essential step for the control of microbial invasion or tissue injury as well as for the maintenance of tissue homeostasis under a variety of noxious conditions. One of the most intriguing aspect of studying inflammation is the plurality of the inflammatory mediators that are continuously discovered (microRNAs, adipokines, inflammasomes and the danger signals, etc.) and their effects on target tissues. Several studies have demonstrated that inflammatory response represents the “common soil”of the multifactorial diseases, encompassing both chronic inflammatory rheumatic disorders and a wide variety of conditions including type 2 diabetes, cardiovascular and neurodegenerative diseases, obesity, cancer, asthma, and ageing. While the inflammatory response observed in the rheumatic disorders seems to be triggered by infection and injury, i.e. the main inducers of inflammation, in the other conditions mentioned it appears to be supported by tissue malfunction or homeostatic imbalance. In the present review, we discuss the data emerged from research on inflammatory mediators sustaining multifactorial diseases.

Significance for a baker:

This study discusses inflammatory response as a key element of multifactorial diseases such as type 2 diabetes, cardiovascular and neurodegenerative diseases, inflammatory bowel diseases, obesity, cancer, asthma, and ageing. This article explains some of the connections between consumption of dietary fibre and reduced inflammation.

Qualify in Baking as Lifestyle Medicine

All reasonable care is taken when writing about health aspects of bread, but the information it contains is not intended to take the place of treatment by a qualified medical practitioner. You must seek professional advice if you are in any doubt about any medical condition. Any application of the ideas and information contained on this website is at the reader's sole discretion and risk.

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