Reference Number: 482
Importance: Increased dietary potassium intake is thought to be associated with low blood pressure (BP). Whether potassium supplementation may be used as an antihypertensive agent is a question that should be answered.
Objective: To assess the effect of oral potassium supplementation on blood pressure in patients with primary hypertension.
Search methods: We searched Medline, Web of Science, Scopus, Cochrane Central Register of Controlled Trials until October 2016. We also screened reference lists of articles and previous reviews. We applied no language restrictions.
Selection criteria: We included randomized placebo-controlled clinical trials addressing the effect of potassium supplementation on primary hypertension for a minimum of 4 weeks.
Data collection and analysis: We extracted data on systolic and diastolic BP (SBP and DBP) at the final follow-up. We explored the heterogeneity across studies using Cochran’s test and I2 statistic and assessed the probability of publication bias using Begg’s and Egger’s tests. We reported the mean difference (MD) of SBP and DBP in a random-effects model.
Results: We found a total of 9059 articles and included 23 trials with 1213 participants. Compared to placebo, potassium supplementation resulted in modest but significant reductions in both SBP (MD -4.25 mmHg; 95% CI: -5.96 to -2.53; I2 = 41%) and DBP (MD -2.53 mmHg; 95% CI: -4.05 to -1.02; I2 = 65%). According to the change-score analysis, based on 8 out of 23 trials, compared to baseline, the mean changes in SBP (MD -8.89 mmHg; 95% CI: -13.67 to -4.11) and DBP (MD -6.42 mmHg; 95% CI: -10.99 to -1.84) was significantly higher in the intervention group than the control group.
Conclusions: Our findings indicated that potassium supplementation is a safe medication with no important adverse effects that has a modest but significant impact BP and may be recommended as an adjuvant antihypertensive agent for patients with essential hypertension.
Significance of this study to the baker:
Potassium is well known for its ability to lower blood pressure and may be used as a supplementation for individuals with hypertension (high blood pressure). Foods rich in potassium are often used within our recipes, and our botanical blended flour here at the Sourdough School. These include bananas, butternut squash, lentils, milk, yoghurt, cashews, almonds and dried fruits such as apricots and raisins.