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Learn to bake, eat, and share the healthiest bread in the world. Discover how to bake as Lifestyle Medicine from the walled gardens of Dr Vanessa Kimbell’s beautiful Victorian home in rural Northamptonshire in the UK, where we train healthcare professionals, teach bakers, and support individuals to bake personalised bread using nutrigenetics and gut health assessments.

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214 - ‘Triggering Akkermansia with dietary polyphenols: A new weapon to combat the metabolic syndrome?’. Gut Microbes. 7(2), 146-153

Reference Number: 214

Year: 2016

Authors: Anhe F.F., et al

Link: Link to original paper

Health: Gut Microbiome - Creating Healthier Bread to Support Optimal Gut Health | Weight Management

Nutrition: Polyphenols

Inclusions: Berries>Cranberries | Pomegranates

Summary

The gut and its bacterial colonizers are now well characterized as key players in whole-body metabolism, opening new avenues of research and generating great expectation for new treatments against obesity and its cardiometabolic complications. As diet is the main environmental factor affecting the gut microbiota, it has been suggested that fruits and vegetables, whose consumption is strongly associated with a healthy lifestyle, may carry phytochemicals that could help maintain intestinal homeostasis and metabolic health. We recently demonstrated that oral administration of a cranberry extract rich in polyphenols prevented diet-induced obesity and several detrimental features of the metabolic syndrome in association with a remarkable increase in the abundance of the mucin-degrading bacterium Akkermansia in the gut microbiota of mice. This addendum provides an extended discussion in light of recent discoveries suggesting a mechanistic link between polyphenols and Akkermansia, also contemplating how this unique microorganism may be exploited to fight the metabolic syndrome.

 

SIGNIFICANCE OF THIS STUDY

Previous work showed the potential of cranberry juice to increase the population of Akkermansia bacteria in the gut. These bacteria have been linked to positive health effects in helping prevent obesity. This paper suggests the best way to encourage a healthy population of these bacteria in the gut microbiome is through a diet rich in polyphenols from fruit and vegetables, rather than taking them as a probiotic because of potential risks identified in some people.

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All reasonable care is taken when advising about health aspects of bread, but the information that we share is not intended to take the place of treatment by a qualified medical practitioner. You must seek professional advice if you are in any doubt about any medical condition. Any application of the ideas and information contained on this website is at the reader's sole discretion and risk.

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