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436 - ‘Metabolomic response to coffee consumption application toa three-stage clinical trial’. Journal of Internal Medicine. 283(6): P544-557

Reference Number: 436

Year: 2018

Authors: M. C. Cornelis, Erlund G, A Michelotti, C. Herder, J. A. Westerhuis, J. Tuomilehto

Link: Link to original paper

Nutrition: Polyphenols | Prebiotic

Summary

Background

Coffee is widely consumed and contains many bioactive compounds, any of which may impact pathways related to disease development.

Objective

To identify individual metabolite changes in response to coffee.

Methods

We profiled the metabolome of fasting serum samples collected from a previously reported single?blinded, three?stage clinical trial. Forty?seven habitual coffee consumers refrained from drinking coffee for 1 month, consumed four cups of coffee/day in the second month and eight cups/day in the third month. Samples collected after each coffee stage were subject to nontargeted metabolomic profiling using UPLC?ESI?MS/MS. A total of 733 metabolites were included for univariate and multivariate analyses.

Results

A total of 115 metabolites were significantly associated with coffee intake (P < 0.05 and Q < 0.05). Eighty?two were of known identity and mapped to one of 33 predefined biological pathways. We observed a significant enrichment of metabolite members of five pathways (P < 0.05): (i) xanthine metabolism: includes caffeine metabolites, (ii) benzoate metabolism: reflects polyphenol metabolite products of gut microbiota metabolism, (iii) steroid: novel but may reflect phytosterol content of coffee, (iv) fatty acid metabolism (acylcholine): novel link to coffee and (v) endocannabinoid: novel link to coffee.

Conclusions

The novel metabolites and candidate pathways we have identified may provide new insight into the mechanisms by which coffee may be exerting its health effects.

 

Significance of this study:

This shows that in some people, coffee may exert positive health benefits due to its polyphenol content, and the metabolism of these polyphenols by the gut microbiota.

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All reasonable care is taken when advising about health aspects of bread, but the information that we share is not intended to take the place of treatment by a qualified medical practitioner. You must seek professional advice if you are in any doubt about any medical condition. Any application of the ideas and information contained on this website is at the reader's sole discretion and risk.

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