Reference Number: 651
Year: 2019
Link: Link to original paper
Health: Lifestyle / Sleep
Nutrition: B Vitamins
Summary
Abstract
Insomnia means difficulty in falling asleep and/or staying asleep. Insomnia commonly leads to daytime sleepiness, lethargy, and a general feeling of being unwell. The most common treatment of insomnia includes GABAA receptor positive allosteric modulators or Melatonin agonists. Our study aimed to evaluate the efficacy of Magnesium- melatonin-vitamin B complex supplement in the treatment of insomnia. The study included 60 patients diagnosed with insomnia. The patients were randomly divided into study group (N = 30), and control group (N = 30), and study group was treated with Magnesium-melatonin-vitamin B complex (one dose contains 175 mg liposomal magnesium oxide, 10 mg Vit B6, 16 ?g vit B12, melatonin 1 mg, Extrafolate-S 600 ?g) once a day 1 hour before sleep, during the 3 months. The severity of insomnia symptoms was measured by self-reported Athens insomnia scale (AIS), with a cut-off score by Soldatos (AIS score ? 6). Mean AIS score at zero points was 14.93 ± 3.778 in the study group and 14.37 ± 4.081 in the control group (p = 0.476), indicating the compatibility of the groups, and both scores correspond to mild to moderate insomnia. Mean AIS score after 3 months of the Magnesium- melatonin- vitamin B complex supplementation was 10.50 ± 4.21 corresponding to mild insomnia, while median AIS score in the control group was 15.13 ± 3.76 which is referred to moderate insomnia, and difference among groups was significant (p = 0.000). Our founding’s indicating that 3 months of the Magnesiummelatonin-vitamin B complex supplementation has a beneficial effect in the treatment of insomnia regardless of cause.
Summary
Our findings indicate that 3 months of the Magnesium-melatonin-vitamin B complex supplementation has a beneficial effect in the treatment of insomnia regardless of cause. According to our results, Magnesium-melatonin-vitamin B complex augmentation improves AIS and CGI-S score with statistical significance relative to the control group. The global improvement according to the CGI-I score, was minimal but significant different compared with the control group where there was no change.
Significance of this study to the baker
A randomized, double-blind, placebo-controlled study of vitamin B6 and B vitamins on the effects on dreaming and sleep showed no significant differences in the B6-treated group compared with the placebo. A complex of magnesium in combination with Vitamin B-6 showed a significant improvement in sleep patterns. Wholegrain flour is naturally high in B vitamins, fermentation facilitates more bioavailability of B vitamins (read more in this study). Sunflower and Pumpkin seeds are definitely the winner when it comes to magnesium, with 535 mg per 100 g. Other great sources to boost your magnesium intake include flax seeds (392 mg), sesame seeds (340 mg) and chia seeds (335 mg). A great combination would be a wholegrain seeded tin.
