634 - ‘The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota’. Neuroscience & Biobehavioral Reviews. Volume 128, Pages 437-453

Reference Number: 634

Year: 2021

Authors: Giuseppe Annunziata et al.

Link: Link to original paper

Health: Alzheimer’s disease | Gut Microbiome - Creating Healthier Bread to Support Optimal Gut Health | Immune response | Parkinson's disease

Nutrition: Polyphenols

Summary

Abstract

Neurodegenerative disorders, particularly in the elderly population, represent one of the most pressing social and health-care problems in the world. Besides the well-established role of both oxidative stress and inflammation, alterations of the immune response have been found to be closely linked to the development of neurodegenerative diseases. Interestingly, various scientific evidence reported that an altered gut microbiota composition may contribute to the development of neuroinflammatory disorders. This leads to the proposal of the concept of the gut-brain-immune axis. In this scenario, polyphenols play a pivotal role due to their ability to exert neuroprotective, immunomodulatory and microbiota-remodeling activities. In the present review, we summarized the available literature to provide a scientific evidence regarding this neuroprotective and immunomodulatory effects and the interaction with gut microbiota of polyphenols and, the main signaling pathways involved that can explain their potential therapeutic application in neurodegenerative diseases.

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