603 - ‘Whole grain consumption and risk of colorectal cancer: a population-based cohort of 60,000 women’. British Journal of Cancer. 92(9): 1803–1807

Reference Number: 603

Year: 2005

Authors: SC Larsson, E Giovannucci, L Bergkvist and A Wolk

Link: Link to original paper

Health: Cancer | Colorectal Cancer

Nutrition: Fibre | Whole grain

Summary

Abstract

We examined prospectively the association between whole grain consumption and colorectal cancer risk in the population-based Swedish Mammography Cohort. A total of 61?433 women completed a food-frequency questionnaire at baseline (1987–1990) and, through linkage with the Swedish Cancer Registry, 805 incident cases of colorectal cancer were identified during a mean follow-up of 14.8 years. High consumption of whole grains was associated with a lower risk of colon cancer, but not of rectal cancer. The multivariate rate ratio (RR) of colon cancer for the top category of whole grain consumption (?4.5?servings?day^?1) compared with the bottom category (<1.5?servings?day^?1) was 0.67 (95% confidence interval (CI), 0.47–0.96; P-value for trend=0.06). The corresponding RR after excluding cases occurring within the first 2 years of follow-up was 0.65 (95% CI, 0.45–0.94; P-value for trend=0.04). Our findings suggest that high consumption of whole grains may decrease the risk of colon cancer in women.

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